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Inhibition of glycogen breakdown by imino sugars in vitro and in vivo.

Abstract:

The imino sugar N-butyldeoxynojirimycin (NB-DNJ) is a glucose analogue which inhibits the glycoprotein N-glycan processing enzymes alpha-glucosidases I and II and the ceramide glucosyltransferase that catalyses the first step of glycosphingolipid biosynthesis. This and other N-alkylated DNJ compounds have the potential to inhibit other glucosidase, including acid alpha-glucosidase and alpha-1,6-glucosidase, enzymes involved in glycogen breakdown. We have investigated the effect of NB-DNJ and ...

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Publication status:
Published

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Publisher copy:
10.1016/j.bcp.2003.09.036

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Biochemical pharmacology
Volume:
67
Issue:
4
Pages:
697-705
Publication date:
2004-02-05
DOI:
EISSN:
1873-2968
ISSN:
0006-2952
URN:
uuid:7dc587e2-cd6b-4a28-b27b-96cb6fa862d0
Source identifiers:
101009
Local pid:
pubs:101009

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