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Impact of renal function on the effects of LDL cholesterol lowering with statin-based regimens: a meta-analysis of individual participant data from 28 randomised trials

Abstract:
Background: Statin therapy is effective for the prevention of coronary heart disease and stroke in patients with mild-to-moderate chronic kidney disease, but its effects in individuals with more advanced disease, particularly those undergoing dialysis, are uncertain. Methods: We did a meta-analysis of individual participant data from 28 trials (n=183 419), examining effects of statin-based therapy on major vascular events (major coronary event [non-fatal m... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/S2213-8587(16)30156-5

Authors


Cholesterol Treatment Trialists' Collaboration More by this author
More by this author
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
More by this author
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
More by this author
Department:
Oxford, MSD, Nuffield Department of Population Health
More by this author
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
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Medical Research Council More from this funder
British Heart Foundation More from this funder
Cancer Research UK More from this funder
Australian National Health and Medical Research Council More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Diabetes and Endocrinology Journal website
Volume:
4
Issue:
10
Pages:
829–839
Acceptance date:
2016-06-23
DOI:
EISSN:
2213-8595
ISSN:
2213-8587
Pubs id:
pubs:637374
URN:
uri:7dbdb6a9-d8bf-42bc-bf66-db346e75dc5e
UUID:
7dbdb6a9-d8bf-42bc-bf66-db346e75dc5e
Local pid:
pubs:637374
Paper number:
10

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