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Impact of renal function on the effects of LDL cholesterol lowering with statin-based regimens: a meta-analysis of individual participant data from 28 randomised trials

Abstract:
Background: Statin therapy is effective for the prevention of coronary heart disease and stroke in patients with mild-to-moderate chronic kidney disease, but its effects in individuals with more advanced disease, particularly those undergoing dialysis, are uncertain. Methods: We did a meta-analysis of individual participant data from 28 trials (n=183 419), examining effects of statin-based therapy on major vascular events (major coronary event [non-fatal m... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S2213-8587(16)30156-5

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Population Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Cancer Research UK More from this funder
Australian National Health and Medical Research Council More from this funder
Australian National Heart Foundation More from this funder
Medical Research Council More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Diabetes and Endocrinology Journal website
Volume:
4
Issue:
10
Pages:
829–839
Publication date:
2016-07-29
Acceptance date:
2016-06-23
DOI:
EISSN:
2213-8595
ISSN:
2213-8587
Source identifiers:
637374
Pubs id:
pubs:637374
UUID:
uuid:7dbdb6a9-d8bf-42bc-bf66-db346e75dc5e
Local pid:
pubs:637374
Deposit date:
2016-10-12

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