- Abstract:
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An age-dependent association between variation at the FTO locus and BMI in children has been suggested. We meta-analyzed associations between the FTO locus (rs9939609) and BMI in samples, aged from early infancy to 13 years, from 8 cohorts of European ancestry. We found a positive association between additional minor (A) alleles and BMI from 5.5 years onwards, but an inverse association below age 2.5 years. Modelling median BMI curves for each genotype using the LMS method, we found that carr...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 619.0KB)
-
- Publisher copy:
- 10.1371/journal.pgen.1001307
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Genetics Journal website
- Volume:
- 7
- Issue:
- 2
- Pages:
- Article: e1001307
- Publication date:
- 2011-02-05
- DOI:
- EISSN:
-
1553-7404
- ISSN:
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1553-7390
- URN:
-
uuid:7db4cf85-3c18-4172-8791-a6cb794e3157
- Source identifiers:
-
124534
- Local pid:
- pubs:124534
- Language:
- English
- Keywords:
- Copyright holder:
- Sovio et al.
- Copyright date:
- 2011
- Notes:
- Copyright 2011 Sovio et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development.
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Medical Research Council
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Wellcome Trust
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University of Bristol
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Department of Health
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British Heart Foundation
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