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Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development.

Abstract:

An age-dependent association between variation at the FTO locus and BMI in children has been suggested. We meta-analyzed associations between the FTO locus (rs9939609) and BMI in samples, aged from early infancy to 13 years, from 8 cohorts of European ancestry. We found a positive association between additional minor (A) alleles and BMI from 5.5 years onwards, but an inverse association below age 2.5 years. Modelling median BMI curves for each genotype using the LMS method, we found that carr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1001307

Authors


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Medical Research Council More from this funder
Wellcome Trust More from this funder
University of Bristol More from this funder
Department of Health More from this funder
British Heart Foundation More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
7
Issue:
2
Pages:
Article: e1001307
Publication date:
2011-02-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:7db4cf85-3c18-4172-8791-a6cb794e3157
Source identifiers:
124534
Local pid:
pubs:124534

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