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A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.

Abstract:

Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human ILC2s express skin homing receptors and infiltrate the skin after allergen challenge, where they produce the type 2 cytokines IL-5 and IL-13. Skin-derived ILC2s express the IL-33 receptor ST2, which is up-regulated during activation, and are enriched in lesional skin biopsies from atopic patients. Signaling via IL-33 induces type 2 cytokine and amphiregulin expression, and incr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1084/jem.20130351

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
Barlow, JL More by this author
Saunders, SP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
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Medical Research Council More from this funder
Barrie Trust More from this funder
National Institute of Health Research More from this funder
Comprehensive Local Research Network More from this funder
Wellcome Trust More from this funder
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Publisher:
Rockefeller University Press. Publisher's website
Journal:
The Journal of Experimental Medicine Journal website
Volume:
210
Issue:
13
Pages:
2939-2950
Publication date:
2013-12-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:7da624fe-a335-4eb9-9efd-a1930dfa6d1d
Source identifiers:
441708
Local pid:
pubs:441708

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