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Evolutionary history of Tibetans inferred from whole-genome sequencing.

Abstract:

The indigenous people of the Tibetan Plateau have been the subject of much recent interest because of their unique genetic adaptations to high altitude. Recent studies have demonstrated that the Tibetan EPAS1 haplotype is involved in high altitude-adaptation and originated in an archaic Denisovan-related population. We sequenced the whole-genomes of 27 Tibetans and conducted analyses to infer a detailed history of demography and natural selection of this population. We detected evidence of po...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1006675

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Funding agency for:
Petousi, N
University of Luxembourg More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
13
Issue:
4
Pages:
e1006675
Publication date:
2017-04-05
Acceptance date:
2017-03-08
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Pubs id:
pubs:692374
URN:
uri:7d98a200-64ac-44cb-97fc-6ee52cbf983b
UUID:
uuid:7d98a200-64ac-44cb-97fc-6ee52cbf983b
Local pid:
pubs:692374
Language:
English
Keywords:

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