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HIV-1 Specific CD4 Responses in Primary HIV-1 Infection predict disease progression in the SPARTAC Trial

Abstract:

Objectives Immune factors determining clinical progression following HIV-1 infection remain unclear. The SPARTAC trial randomised 366 participants in primary HIV infection (PHI) to different short course therapies. The aim of this study was to investigate how early immune responses in PHI impacted clinical progression in SPARTAC. Design and Methods Participants with PHI recruited to the SPARTAC trial were sampled at enrolment, prior to commencing any therapy. HIV-1 specific CD4 and CD8 ELISpo...

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Publication status:
Published
Peer review status:
Peer Reviewed

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
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More from this funder
Funding agency for:
Frater, J
Publisher:
Wolters Kluwer Publisher's website
Journal:
AIDS Journal website
Volume:
28
Issue:
5
Pages:
699-708
Publication date:
2013-12-01
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
URN:
uuid:7d8c6e16-c850-46f4-871b-53e64b064002
Source identifiers:
438000
Local pid:
pubs:438000

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