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Journal article

Superiority and non-inferiority: Two sides of the same coin?

Abstract:

Background

The classification of phase 3 trials as superiority or non-inferiority has become routine, and it is widely accepted that there are important differences between the two types of trial in their design, analysis and interpretation.

Main text

There is a clear rationale for the superiority/non-inferiority framework in the context of regulatory trials. The focus of our article is non-regulatory trials with a public health objective. First, using two example...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13063-018-2885-z

Authors


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Role:
Author
ORCID:
0000-0003-1836-4446
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
NPEU
Role:
Author
Publisher:
BioMed Central Publisher's website
Journal:
Trials Journal website
Volume:
19
Issue:
1
Pages:
499
Publication date:
2018-09-17
Acceptance date:
2018-08-29
DOI:
EISSN:
1745-6215
ISSN:
1745-6215
Pubs id:
pubs:920811
URN:
uri:7d7f6c16-dfdb-4c35-804f-8ee497bf0b90
UUID:
uuid:7d7f6c16-dfdb-4c35-804f-8ee497bf0b90
Local pid:
pubs:920811
Language:
English
Keywords:

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