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Activation of NFκB dependent apoptotic pathway in pancreatic islet cells by hypoxia.

Abstract:

Insulin producing β-cells are exposed to hypoxic stress in the early period after islet transplantation. Although it has been suggested that hypoxia leads to islet loss, the underlying mechanisms are unclear. In this study, the early transcriptional profiles of b cell response to hypoxia were determined by using the Affymetrix Murine Genome Array U74Av2 GeneChip (about 12,422 genes). In addition to the upregulation of genes associated with glycolysis, genes related to apoptosis and stress res...

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Publisher copy:
10.4161/isl.1.1.8530

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
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Journal:
Islets
Volume:
1
Issue:
1
Pages:
19-25
Publication date:
2009-01-01
DOI:
EISSN:
1938-2022
ISSN:
1938-2014
URN:
uuid:7d7cc182-568d-4ff5-b691-7a5674534e1c
Source identifiers:
401688
Local pid:
pubs:401688

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