A logical theranostic CRISPR/Cas system and novel carriers for its delivery

Thesis

Nucleic acid-based therapies hold the promise to treat many diseases in a way that was not previously possible: at the genetic level. Unfortunately, these therapies are limited by a lack of efficient delivery systems. It is challenging to synthesise new delivery systems that can effciently reach specific tissues. This is because new delivery systems need to overcome many sophisticated biological barriers, from avoiding the immune system to escaping the endosomal pathway. Better delivery s...

Expand abstract

Authors: Garcia Guerra, A

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Nanomedicine; gene therapy; nucleic acid delivery; CRISPR
• Subjects: drug delivery; bioengieering; Biophysics