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Journal article

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

Abstract:

The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs in KITLG and a region of 9q32. In a bivariate analysis combining the nevus results with a recent melanoma GWAS meta-analysis (12,874 cases, 23,203 controls), SNPs near GPRC5A, CYP1B1, PPARGC1B, HDAC...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-06649-5

Authors


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Role:
Author
ORCID:
0000-0001-7227-632X

Contributors

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Name:
Department of Health
Grant:
NF-SI-0514-10027
NF-SI-0507-10228
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Name:
Cancer Research UK
Grant:
10589
16565
19167
More from this funder
Name:
Medical Research Council
Grant:
MC_UU_00011/1
MR/L01629X/1
MC_UU_12013/4
Publisher:
Nature Research
Journal:
Nature Communications More from this journal
Volume:
9
Article number:
4774
Publication date:
2018-11-14
Acceptance date:
2018-09-13
DOI:
EISSN:
2041-1723
Pmid:
30429480
Language:
English
Keywords:
Pubs id:
pubs:977433
UUID:
uuid:7d69dd27-e729-4fb0-aa09-663d6a0f2e5a
Local pid:
pubs:977433
Source identifiers:
977433
Deposit date:
2019-04-05

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