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Behavioural recovery following transplantation of substantia nigra in rats subjected to 6-OHDA lesions of the nigrostriatal pathway. II. Bilateral lesions.

Abstract:

Rats with a unilateral transplant of embryonic substantia nigra, placed in a cortical cavity overlying the caudate-putamen, were compared with control animals on a range of behavioral tests following bilateral 6-OHDA lesions of the ascending dopaminergic nigrostriatal pathway. Tests designed to reveal behavioural asymmetry--such as spontaneous, tail-pinch and amphetamine-induced rotation, sensorimotor orientation, and side preference in a T-maze--revealed that the rats with bilateral 6-OHDA l...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Brain research
Volume:
229
Issue:
2
Pages:
457-470
Publication date:
1981-12-05
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
URN:
uuid:7d68b44c-d105-4070-a452-7f34b08dda85
Source identifiers:
30598
Local pid:
pubs:30598

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