Journal article
Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees
- Abstract:
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The microvasculature plays a key role in oxygen transport in the mammalian brain. Despite the close coupling between cerebral vascular geometry and local oxygen demand, recent experiments have reported that microvascular occlusions can lead to unexpected distant tissue hypoxia and infarction. To better understand the spatial correlation between the hypoxic regions and the occlusion sites, we used both in vivo experiments and in silico simulations to investigate the effects of occlusions in cerebral penetrating arteriole trees on tissue hypoxia. In a rat model of microembolisation, 25 μm microspheres were injected through the carotid artery to occlude penetrating arterioles. In representative models of human cortical columns, the penetrating arterioles were occluded by simulating the transport of microspheres of the same size and the oxygen transport was simulated using a Green’s function method. The locations of microspheres and hypoxic regions were segmented, and two novel distance analyses were implemented to study their spatial correlation. The distant hypoxic regions were found to be present in both experiments and simulations, and mainly due to the hypoperfusion in the region downstream of the occlusion site. Furthermore, a reasonable agreement for the spatial correlation between hypoxic regions and occlusion sites is shown between experiments and simulations, which indicates the good applicability of in silico models in understanding the response of cerebral blood flow and oxygen transport to microemboli.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.3MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pcbi.1010166
Authors
- Publisher:
- Public Library of Science
- Journal:
- PLoS Computational Biology More from this journal
- Volume:
- 18
- Issue:
- 8
- Article number:
- e1010166
- Publication date:
- 2022-08-05
- Acceptance date:
- 2022-07-14
- DOI:
- EISSN:
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1553-7358
- ISSN:
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1553-734X
- Pmid:
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35930591
- Language:
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English
- Keywords:
- Pubs id:
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1279138
- Local pid:
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pubs:1279138
- Deposit date:
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2022-11-24
Terms of use
- Copyright holder:
- Xue et al.
- Copyright date:
- 2022
- Rights statement:
- © 2022 Xue et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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