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Cytokine profiles in Malawian children presenting with uncomplicated malaria, severe malarial anemia and cerebral malaria.

Abstract:

Pro-inflammatory cytokines are involved in clearance of Plasmodium falciparum, and very high levels of these cytokines have been implicated in the pathogenesis of severe malaria. In order to determine how cytokines vary with disease severity and syndrome, we enrolled Malawian children presenting with cerebral malaria (CM), severe malarial anaemia (SMA) and uncomplicated malaria (UCM), and healthy controls. We analysed serum cytokine concentrations in acute infection, and in convalescence. Wit...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/CVI.00533-16

Authors


Mandala, WL More by this author
Msefula, CL More by this author
Gondwe, EN More by this author
Drayson, MT More by this author
Molyneux, ME More by this author
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Gates Malaria Partnership More from this funder
More from this funder
Grant:
067902/Z/02/Z; 074124/Z/04/Z
GlaxoSmithKline More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Clinical and Vaccine Immunology Journal website
Volume:
24
Issue:
4
Pages:
e00533-16
Publication date:
2017-01-25
Acceptance date:
2017-01-25
DOI:
EISSN:
1556-679X
ISSN:
1556-6811
Pubs id:
pubs:673497
URN:
uri:7d5cac6f-4f01-4aed-aeba-7303b3e61f2d
UUID:
uuid:7d5cac6f-4f01-4aed-aeba-7303b3e61f2d
Local pid:
pubs:673497
Language:
English
Keywords:

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