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A mechanism for value-guided choice based on the excitation-inhibition balance in prefrontal cortex.

Abstract:
Although the ventromedial prefrontal cortex (vmPFC) has long been implicated in reward-guided decision making, its exact role in this process has remained an unresolved issue. Here we show that, in accordance with models of decision making, vmPFC concentrations of GABA and glutamate in human volunteers predict both behavioral performance and the dynamics of a neural value comparison signal. These data provide evidence for a neural competition mechanism in vmPFC that supports value-guided choice.
Publication status:
Published

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Publisher copy:
10.1038/nn.3140

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Experimental Psychology
Journal:
Nature neuroscience
Volume:
15
Issue:
7
Pages:
960-961
Publication date:
2012-07-05
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:7d5ab2cb-088c-480b-bb65-fface2ae7f27
Source identifiers:
339809
Local pid:
pubs:339809

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