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Isometric contraction of dupuytren's myofibroblasts is inhibited by blocking intercellular junctions

Abstract:

Myofibroblasts (MFs) are responsible for both physiological wound and scar contraction. However, it is not known whether these cells act individually to contract the surrounding matrix or whether they behave in a coordinated manner. Therefore, we studied intercellular junctions of primary human MFs derived from patients with Dupuytren's disease, a fibrotic disorder of the dermis and subdermal tissues of the palm. The cells were maintained in anchored three-dimensional collagen lattices to clo...

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Publisher copy:
10.1038/jid.2013.219

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Journal:
Journal of Investigative Dermatology
Volume:
133
Issue:
12
Pages:
2664-2671
Publication date:
2013-12-05
DOI:
EISSN:
1523-1747
ISSN:
0022-202X
URN:
uuid:7d567025-464b-46c7-b648-b61ebbb21121
Source identifiers:
440582
Local pid:
pubs:440582
Language:
English

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