Journal article
Differential thermostability and response to cystic fibrosis transmembrane conductance regulator (CFTR) potentiators of human and mouse F508del-CFTR
- Abstract:
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Cross-species comparative studies have highlighted differences between human and mouse cystic fibrosis transmembrane conductance regulator (CFTR), the epithelial Cl− channel defective in cystic fibrosis (CF). Here, we compare the impact of the most common CF mutation F508del on the function of human and mouse CFTR heterologously expressed in mammalian cells and their response to CFTR modulators using the iodide efflux and patch-clamp techniques. Once delivered to the plasma membrane, human F5...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 4.3MB, Terms of use)
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- Publisher copy:
- 10.1152/ajplung.00034.2019
Authors
Bibliographic Details
- Publisher:
- American Physiological Society
- Journal:
- AJP - Lung Cellular and Molecular Physiology More from this journal
- Volume:
- 317
- Issue:
- 1
- Pages:
- L71-L86
- Publication date:
- 2019-04-10
- Acceptance date:
- 2019-04-04
- DOI:
- EISSN:
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1522-1504
- ISSN:
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1040-0605
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:995053
- UUID:
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uuid:7d504c40-a77e-4e90-8817-d4edb0cbe2a8
- Local pid:
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pubs:995053
- Source identifiers:
-
995053
- Deposit date:
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2019-04-30
Terms of use
- Copyright holder:
- *Name of copyright holder*
- Copyright date:
- 2019
- Notes:
- © 2019 the American Physiological Society. Licensed under Creative Commons Attribution CC-BY 4.0 : © the American Physiological Society.
- Licence:
- CC Attribution (CC BY)
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