The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia.

Journal article

An internal tandem duplication in the fms-like tyrosine kinase 3 gene (FLT3/ITD) is associated with poor prognosis in acute myeloid leukemia (AML), but the impact of mutant level, size, and interaction with nucleophosmin 1 (NPM1) mutations remains controversial. We evaluated these characteristics in a large cohort of young adult AML patients. There was a highly significant trend for worsening in relapse risk (RR) and overall survival (OS) with increasing FLT3/ITD mutant level (P < .001 for...

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Authors: Gale, R; Green, C; Allen, C; Mead, A; Burnett, A

• Journal: Blood
• Volume: 111
• Issue: 5
• Pages: 2776-2784
• Publication date: 2008-03-01
• DOI: 10.1182/blood-2007-08-109090
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Demography; Treatment Outcome; Tandem Repeat Sequences; Multivariate Analysis; Leukemia, Myeloid, Acute; X Chromosome Inactivation; Nuclear Proteins; Humans; fms-Like Tyrosine Kinase 3; Clone Cells; Adult; Female; Middle Aged; Gene Duplication; Medical Research Council Adult Leukaemia Working Party; Adolescent; Cohort Studies; Karyotyping; Male