- Abstract:
-
The terms 'adverse drug effects' and 'adverse drug reactions' are commonly used interchangeably, but they have different implications. Adverse drug reactions arise when a compound (e.g. a drug or metabolite, a contaminant or adulterant) is distributed in the same place as a body tissue (e.g. a receptor, enzyme, or ion channel), and the encounter results in an adverse effect (a physiological or pathological change), which results in a clinically appreciable adverse reaction. Both the adverse e...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s40264-013-0019-9
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- Journal:
- Drug safety
- Volume:
- 36
- Issue:
- 3
- Pages:
- 147-153
- Publication date:
- 2013-03-05
- DOI:
- ISSN:
-
0114-5916
- URN:
-
uuid:7d498a48-6821-4bdd-9eff-2614e9c84270
- Source identifiers:
-
387149
- Local pid:
- pubs:387149
- Copyright date:
- 2013
Journal article
Distinguishing hazards and harms, adverse drug effects and adverse drug reactions : implications for drug development, clinical trials, pharmacovigilance, biomarkers, and monitoring.
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