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Differences between bisphosphonates in binding affinities for hydroxyapatite.

Abstract:

Bisphosphonates (BPs) inhibit bone resorption and are widely used for the treatment of bone diseases, including osteoporosis. BPs are also being studied for their effects on hydroxyapatite (HAP)-containing biomaterials. There is a growing appreciation that there are hitherto unexpected differences among BPs in their mineral binding affinities that affect their pharmacological and biological properties. To study these differences, we have developed a method based on fast performance liquid chr...

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Publication status:
Published

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Publisher copy:
10.1002/jbm.b.31500

Authors


Lawson, MA More by this author
Barnett, BL More by this author
Triffitt, JT More by this author
Phipps, RJ More by this author
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Journal:
Journal of biomedical materials research. Part B, Applied biomaterials
Volume:
92
Issue:
1
Pages:
149-155
Publication date:
2010-01-05
DOI:
EISSN:
1552-4981
ISSN:
1552-4973
URN:
uuid:7d48a72f-2db8-4327-a829-824103e6c620
Source identifiers:
107416
Local pid:
pubs:107416

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