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Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics.

Abstract:

SUMMARY: Advances in cDNA and monoclonal antibody technology in the 1980s fuelled the discovery and characterization of the properties of cytokines. It became apparent that because cytokines were expressed in tissues derived from autoimmune diseases, they were likely to be of fundamental importance in disease pathogenesis and developing a new class of biological therapeutics. In this review, we describe the history of bench to bedside translation of work that led to the identification of tum...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Immunological reviews
Volume:
223
Issue:
1
Pages:
7-19
Publication date:
2008-06-05
DOI:
EISSN:
1600-065X
ISSN:
0105-2896
URN:
uuid:7d4094b8-1d4f-4e47-b10a-0b201281cb93
Source identifiers:
224491
Local pid:
pubs:224491

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