A mathematical model of cellular metabolism during ischemic stroke and hypothermia.

Journal article

Abstract:: Stroke is a major cause of death and disability worldwide. Therapeutic hypothermia is a potentially useful neuroprotective treatment. A mathematical model of brain metabolism during stroke is extended here to simulate the effect of hypothermia on cell survival. Temperature decreases were set to reduce chemical reaction rates and slow diffusion through ion channels according to the Q10 rule. Heat delivery to tissues was set to depend on metabolic heat generation rate and perfusion. Two cooling...
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Institution:

University of Oxford

Division:

MPLS

Department:

Engineering Science

Role:

Author

Role:

Author

Role:

Author

Journal:: IEEE transactions on bio-medical engineering More from this journal
Volume:: 61
Issue:: 2
Pages:: 484-490
Publication date:: 2014-02-01
DOI:: 10.1109/tbme.2013.2282603
EISSN:: 1558-2531
ISSN:: 0018-9294

Language:: English
Keywords:: Cell Hypoxia

Stroke

Computer Simulation

Rats

Brain

Hypothermia

Animals

Hypothermia, Induced

Models, Biological
Pubs id:: pubs:394882
UUID:: uuid:7d33dda4-a737-4900-9633-3c22e8f44755
Local pid:: pubs:394882
Source identifiers:: 394882
Deposit date:: 2014-02-26

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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