Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development.

Journal article

The mechanisms by which arterial fate is established and maintained are not clearly understood. Although a number of signaling pathways and transcriptional regulators have been implicated in arterio-venous differentiation, none are essential for arterial formation, and the manner in which widely expressed factors may achieve arterial-specific gene regulation is unclear. Using both mouse and zebrafish models, we demonstrate here that arterial specification is regulated combinatorially by Notch...

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Authors: Sacilotto, N; Monteiro, R; Fritzsche, M; Becker, P; Sanchez-Del-Campo, L

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 110
• Issue: 29
• Pages: 11893-11898
• Publication date: 2013-07-01
• DOI: 10.1073/pnas.1300805110
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Membrane Proteins; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Receptors, Notch; Cloning, Molecular; Gene Knockdown Techniques; Animals; Zebrafish; SOXF Transcription Factors; Chromatin Immunoprecipitation; Mice; Electrophoretic Mobility Shift Assay; Mice, Transgenic; Immunohistochemistry; Gene Expression Regulation, Developmental; Arteries; In Situ Hybridization; Intracellular Signaling Peptides and Proteins