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Cloning and functional analysis of ascidian Mitf in vivo: insights into the origin of vertebrate pigment cells.

Abstract:

The microphthalmia-associated transcription factor (Mitf) is a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor essential for the development and function of all melanin-producing pigment cells in vertebrates. To elucidate the evolutionary history of Mitf and the antiquity of its association with pigment cells, we have isolated and characterized HrMitf, a sole member of the Mitf-TFE bHLH-ZIP subfamily in the ascidian Halocynthia roretzi. Maternal HrMitf mRNA is detected i...

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Publication status:
Published

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Publisher copy:
10.1016/j.mod.2003.08.009

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Journal:
Mechanisms of development
Volume:
120
Issue:
12
Pages:
1489-1504
Publication date:
2003-12-05
DOI:
EISSN:
1872-6356
ISSN:
0925-4773
URN:
uuid:7d2d8a7a-3b5d-4351-9ade-3207342b3979
Source identifiers:
92997
Local pid:
pubs:92997

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