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Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 channels in mouse carotid body type-1 cells.

Abstract:

In rat arterial chemoreceptors, background potassium channels play an important role in maintaining resting membrane potential and promoting depolarization and excitation in response to hypoxia or acidosis. It has been suggested that these channels are a heterodimer of TASK-1 and TASK-3 based on their similarity to heterologously expressed TASK-1/3 fusion proteins. In this study, we sought to confirm the identity of these channels through germline ablation of Task-1 (Kcnk3) and Task-3 (Kcnk9)...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
The Journal of physiology
Volume:
591
Issue:
Pt 23
Pages:
5977-5998
Publication date:
2013-12-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:7d2d72e8-1ea5-4c94-a922-768a45b8f4e8
Source identifiers:
428084
Local pid:
pubs:428084

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