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Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen.

Abstract:

Many genetically modified mouse strains are now available on a C57BL/6 (H-2b) background, a strain that is relatively resistant to collagen-induced arthritis. To facilitate the molecular understanding of autoimmune arthritis, we characterised the induction of arthritis in C57BL/6 mice and then validated the disease as a relevant pre-clinical model for rheumatoid arthritis. C57BL/6 mice were immunised with type II collagen using different protocols, and arthritis incidence, severity, and respo...

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Publication status:
Published

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Publisher copy:
10.1186/ar2319

Authors


Inglis, JJ More by this author
Medghalchi, M More by this author
Andrews, M More by this author
Sandison, A More by this author
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Journal:
Arthritis research and therapy
Volume:
9
Issue:
5
Pages:
R113
Publication date:
2007
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
URN:
uuid:7d1d9ce1-caf0-4530-9561-6566de38963a
Source identifiers:
224013
Local pid:
pubs:224013

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