Prion diseases are fatal, chronic neurodegenerative diseases of mammals, characterized by amyloid deposition, astrogliosis, microglial activation, tissue vacuolation and neuronal loss. In the ME7 model of prion disease in the C57BL/6 J mouse, we have shown previously that these animals display behavioural changes that indicate the onset of neuronal dysfunction. The current study examines the neuropathological correlates of these early behavioural changes. After injection of ME7-infected homog...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record