Journal article icon

Journal article

Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease.

Abstract:

Prion diseases are fatal, chronic neurodegenerative diseases of mammals, characterized by amyloid deposition, astrogliosis, microglial activation, tissue vacuolation and neuronal loss. In the ME7 model of prion disease in the C57BL/6 J mouse, we have shown previously that these animals display behavioural changes that indicate the onset of neuronal dysfunction. The current study examines the neuropathological correlates of these early behavioural changes. After injection of ME7-infected homog...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
The European journal of neuroscience
Volume:
17
Issue:
10
Pages:
2147-2155
Publication date:
2003-05-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:7d1acfcb-67e7-4688-867c-9a3703d13b71
Source identifiers:
310869
Local pid:
pubs:310869

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP