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Translating ribosome affinity purification from C9orf72-associated amyotrophic lateral sclerosis patient-derived iPSC motor neurons

Abstract:

The C9orf72 hexanucleotide repeat expansion [GGGGCC]n is the most common cause of familial amyotrophic lateral sclerosis. The endogenous role of the C9orf72 protein has not been fully characterised, nor how the presence of the repeat expansion affects downstream mechanisms. Numerous cellular and molecular pathologies have been characterised in patient-derived induced pluripotent stem cell (iPSC) motor neuron cultures. This includes the accumulation of nuclear RNA foci and cytopl...

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Subgroup:
Clinical Neurosciences
Research group:
Talbot/ Centre for Motor Neurone Disease
Oxford college:
St Cross College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Subgroup:
Clinical Neurosciences
Research group:
Talbot/ Centre for Motor Neurone Disease
Role:
Supervisor
ORCID:
0000-0003-0776-6431
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Subgroup:
Clinical Neurosciences
Research group:
Talbot/ Centre for Motor Neurone Disease
Role:
Supervisor
ORCID:
0000-0001-5490-1697
Institution:
University of Oxford
Subgroup:
Physiology Anatomy & Genetics
Research group:
Wade-Martins Group
Role:
Examiner
More from this funder
Grant:
Talbot/Oct15/886-792
Programme:
PhD STUDENTSHIP GRANT (Barry Bastin Studentship)
Funding agency for:
Sathyaprakash, C
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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