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Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders

Abstract:

The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is known about the complementary clinical value of brain structural phenotypes when combined with data on cognitive performance and genetic risk. Using data-driven fusion of cortical thickness, surface area, and gray matter density maps (GMD), we found six biologically meaningfu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.nicl.2017.06.014

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Role:
Author
ORCID:
0000-0002-4003-1018
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Grant:
Seventh Framework Programme (FP7/2007-2013, #602450, IMAGEMEND)
Kristian Gerhard Jebsen Foundation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
NeuroImage: Clinical Journal website
Volume:
15
Pages:
719-731
Publication date:
2017-06-09
Acceptance date:
2017-06-09
DOI:
ISSN:
2213-1582
Pubs id:
pubs:703155
URN:
uri:7d1118bb-3ba1-4586-9007-e1a049370b21
UUID:
uuid:7d1118bb-3ba1-4586-9007-e1a049370b21
Local pid:
pubs:703155

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