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Fractionation effects in particle radiotherapy: implications for hypo-fractionation regimes.

Abstract:

The aim is to demonstrate the potential impact of changes in the value of the β parameter in the linear quadratic (LQ) model on the calculation of clinical relative biological effectiveness (RBE) values used for high linear energy transfer (LET) radiotherapy. The parameter RBE(min) is introduced into the LQ formulation to account for possible changes in the β radiosensitivity coefficient with changing LET. The model is used to fit fractionated data under two conditions, where RBE(min) = 1 and...

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Publication status:
Published

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Publisher copy:
10.1088/0031-9155/55/19/005

Authors


Carabe-Fernandez, A More by this author
Hopewell, JW More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Paganetti, H More by this author
Journal:
Physics in medicine and biology
Volume:
55
Issue:
19
Pages:
5685-5700
Publication date:
2010-10-05
DOI:
EISSN:
1361-6560
ISSN:
0031-9155
URN:
uuid:7d0bec78-fae1-4a72-a9d8-87b7f2a6d200
Source identifiers:
132319
Local pid:
pubs:132319

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