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In vivo optical imaging of early osteoarthritis using an antibody specific to damaged arthritic cartilage.

Abstract:

The lack of specific and sensitive serum and radiographic biomarkers for early diagnosis of osteoarthritis (OA) as well as for monitoring subtle changes in disease activity in clinical trials has hampered the development of treatments for OA. We previously showed that 1-11E, a human single chain fragment variable (scFv) specific to collagen type II that has been post-translationally modified by reactive oxidants (ROS-CII), binds exclusively to arthritic cartilage. Here we test the validity of...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13075-015-0898-5

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
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Grant:
Centre for OA Pathogenesis, grant ref. 20205
Publisher:
BioMed Central Publisher's website
Journal:
Arthritis research and therapy Journal website
Volume:
17
Issue:
1
Pages:
376
Publication date:
2015
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
URN:
uuid:7d027a2f-9302-49c6-a5df-657e054086f3
Source identifiers:
586405
Local pid:
pubs:586405
Language:
English
Keywords:

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