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Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

Abstract:

Type 2 diabetes affects over 300 million people, causing severe complications and premature death, yet the underlying molecular mechanisms are largely unknown. Pancreatic islet dysfunction is central in type 2 diabetes pathogenesis, and understanding islet genome regulation could therefore provide valuable mechanistic insights. We have now mapped and examined the function of human islet cis-regulatory networks. We identify genomic sequences that are targeted by islet transcription factors to ...

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Publisher copy:
10.1038/ng.2870

Authors


Pasquali, L More by this author
Gaulton, KJ More by this author
Rodríguez-Seguí, SA More by this author
Mularoni, L More by this author
Miguel-Escalada, I More by this author
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Publisher:
Nature Publishing Group
Journal:
Nature Genetics
Volume:
46
Issue:
2
Pages:
136-143
Publication date:
2014
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:7cf7a35c-f077-44ea-8d11-ec7825883696
Source identifiers:
474081
Local pid:
pubs:474081
Language:
English

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