Journal article icon

Journal article

Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy.

Abstract:

The microtubule-associated protein tau is implicated in various neurodegenerative diseases including Alzheimer's disease, progressive supranuclear palsy and corticobasal degeneration, which are characterized by intracellular accumulation of hyperphosphorylated tau. Mutations in the tau gene MAPT cause frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17). In the human central nervous system, six tau isoforms are expressed, and imbalances in tau isoform ratios are associa...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/srep43198

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Wobst, H
Grant:
War Memorial Scholarship
More from this funder
Grant:
075406/Z/04/A
090532/Z/09/Z
087736/Z/08/Z
073141/Z/03/Z
Medical Research Council More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Publication date:
2017-02-24
Acceptance date:
2017-01-20
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Language:
English
Keywords:
Pubs id:
pubs:682330
UUID:
uuid:7cf24653-a430-48eb-8ffb-d804e388a68e
Local pid:
pubs:682330
Deposit date:
2017-03-08

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP