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Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules.

Abstract:

In both collagen-induced arthritis (CIA) and rheumatoid arthritis, T cells recognize a galactosylated peptide from type II collagen (CII). In this study, we demonstrate that the CII259-273 peptide, galactosylated at lysine 264, in complex with Aq molecules prevented development of CIA in mice and ameliorated chronic relapsing disease. In contrast, nonglycosylated CII259-273/Aq complexes had no such effect. CIA dependent on other MHC class II molecules (Ar/Er) was also down-regulated, indicati...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.176.3.1525

Authors


Dzhambazov, B More by this author
Nandakumar, KS More by this author
Kihlberg, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Molecular Medicine
Holmdahl, R More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
176
Issue:
3
Pages:
1525-1533
Publication date:
2006-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:7ce68e06-e904-4bfe-830c-905b4040185e
Source identifiers:
314766
Local pid:
pubs:314766

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