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PET tau and amyloid-β burden in mild Alzheimer's disease: divergent relationship with age, cognition and cerebrospinal fluid biomarkers

Abstract:
Background Combining PET amyloid-β and tau imaging may be critical for tracking disease progression in Alzheimer’s disease (AD). Objective We sought to characterize the relationship between amyloid-β and tau ligands as well as with other measures of pathology. Methods We conducted a multi-center observational study in early AD (MMSE >20) participants aged 50 to 85 years. The schedule included cognitive assessments (ADAS-Cog) and CSF measur... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3233/JAD-170129

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Department:
Oxford, MSD, Psychiatry
Firouzian, A More by this author
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Department:
Oxford, MSD, Psychiatry
More by this author
Department:
Oxford, MSD, Psychiatry
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Publisher:
IOS Press Publisher's website
Journal:
Journal of Alzheimer's Disease Journal website
Volume:
60
Issue:
1
Pages:
283-293
Publication date:
2017-08-29
Acceptance date:
2017-06-02
DOI:
EISSN:
1875-8908
ISSN:
1387-2877
Pubs id:
pubs:702718
URN:
uri:7cbadd7a-5f6e-4a70-a6fb-b8f4073880c4
UUID:
uuid:7cbadd7a-5f6e-4a70-a6fb-b8f4073880c4
Local pid:
pubs:702718

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