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The invertebrate lysozyme effector ILYS-3 is systemically activated in response to danger signals and confers antimicrobial protection in C. elegans

Abstract:

Little is known about the relative contributions and importance of antibacterial effectors in the nematode C. elegans, despite extensive work on the innate immune responses in this organism. We report an investigation of the expression, function and regulation of the six ilys (invertebrate-type lysozyme) genes of C. elegans. These genes exhibited a surprising variety of tissue-specific expression patterns and responses to starvation or bacterial infection. The most strongly expressed, ilys-3,...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1005826

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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Pathology Dunn School
Chalmers, R More by this author
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Department:
Oxford, MSD, Biochemistry
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Funding agency for:
Vaz, F
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
12
Issue:
8
Pages:
Article: e1005826
Publication date:
2016-08-15
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pubs id:
pubs:640510
URN:
uri:7cbad36e-003f-40e8-aa28-98b226403908
UUID:
uuid:7cbad36e-003f-40e8-aa28-98b226403908
Local pid:
pubs:640510
Language:
English

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