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CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer.

Abstract:

The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript (lncRNA) encompassing the rs6983267 SNP, is highly overexpressed in microsatellite-stable colorectal cancer and promotes tumor growth, metastasis, and chromosomal instability. We demonstrate that MYC, miR-17-5p, and miR-20a are up-regulated by CCAT2 through TCF7L2-mediated transcriptional regulation. We further identify...

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Publication status:
Published

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Publisher copy:
10.1101/gr.152942.112

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Journal:
Genome research
Volume:
23
Issue:
9
Pages:
1446-1461
Publication date:
2013-09-05
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
URN:
uuid:7cb386a5-6a16-4387-94dc-e273a8d69703
Source identifiers:
429527
Local pid:
pubs:429527

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