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Journal article

Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.

Abstract:

The transcriptional co-activators and histone acetyltransferases p300/CREB-binding protein (CBP) interact with CITED2, a transcription factor AP-2 (TFAP2) co-activator. p300/CBP, CITED2, and TFAP2A are essential for normal neural tube and cardiac development. Here we show that p300 and CBP co-activate TFAP2A in the presence of CITED2. TFAP2A transcriptional activity was modestly impaired in p300(+/-) and CBP(+/-) mouse embryonic fibroblasts; this was rescued by ectopic expression of p300/CBP....

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m208144200

Authors


Bragança, J More by this author
Eloranta, JJ More by this author
Bamforth, SD More by this author
Ibbitt, JC More by this author
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Journal:
The Journal of biological chemistry
Volume:
278
Issue:
18
Pages:
16021-16029
Publication date:
2003-05-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:7c91d66f-d2c0-4ce0-9daf-624e20736757
Source identifiers:
110443
Local pid:
pubs:110443

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