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Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.

Abstract:

The locus encompassing the corticosteroidogenic genes CYP11B2 and CYP11B1 is of potential importance in essential hypertension. We analyzed the association of polymorphisms at this locus with risk of essential hypertension, using 2 white case-control collections for discovery (n=3340) and confirmation (n=2929). Single-marker and haplotype analyses were performed, with the CYP11B2 Intron 2 Conversion polymorphism showing strongest association with hypertension in both cohorts and in combined a...

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Publication status:
Published

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Journal:
Hypertension
Volume:
61
Issue:
1
Pages:
232-239
Publication date:
2013-01-05
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
URN:
uuid:7c8d25a5-9e46-4abf-b630-5e0603d56aa3
Source identifiers:
363829
Local pid:
pubs:363829

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