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Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin.

Abstract:

Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by dystrophin deficiency. In normal muscle, dystrophin helps maintain sarcolemmal stability. Dystrophin also recruits neuronal nitric oxide synthase (nNOS) to the sarcolemma. Failure to anchor nNOS to the membrane leads to functional ischemia and aggravates muscle disease in DMD. Over the past two decades, a great variety of therapeutic modalities have been explored to treat DMD. A particularly attractive approach is to incre...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.064808

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Journal:
Journal of cell science
Volume:
123
Issue:
Pt 12
Pages:
2008-2013
Publication date:
2010-06-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:7c885a2f-0f38-4325-9e89-0e47ab9fcab3
Source identifiers:
106873
Local pid:
pubs:106873

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