Journal article
Donepezil for the treatment of agitation in Alzheimer's disease.
- Abstract:
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BACKGROUND: Agitation is a common and distressing symptom in patients with Alzheimer's disease. Cholinesterase inhibitors improve cognitive outcomes in such patients, but the benefits of these drugs for behavioral disturbances are unclear. METHODS: We randomly assigned 272 patients with Alzheimer's disease who had clinically significant agitation and no response to a brief psychosocial treatment program to receive 10 mg of donepezil per day (128 patients) or placebo (131 patients) for 12 week...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 225.5KB)
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- Publisher copy:
- 10.1056/nejmoa066583
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Authors
Funding
Alzheimer's Society
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Bibliographic Details
- Publisher:
- Massachusetts Medical Society Publisher's website
- Journal:
- New England journal of medicine Journal website
- Volume:
- 357
- Issue:
- 14
- Pages:
- 1382-1392
- Publication date:
- 2007-10-01
- DOI:
- EISSN:
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1533-4406
- ISSN:
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0028-4793
- Source identifiers:
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60824
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:60824
- UUID:
-
uuid:7c793175-5022-4a6a-be4e-43efe035946e
- Local pid:
- pubs:60824
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Massachusetts Medical Society
- Copyright date:
- 2007
- Notes:
- From New England Journal of Medicine, Robert J. Howard, Edmund Juszczak, Clive G. Ballard, Peter Bentham, Richard G. Brown, Roger Bullock, Alistair S. Burns, Clive Holmes, Robin Jacoby, Tony Johnson, Martin Knapp, James Lindesay, John T. O'Brien, Gordon Wilcock, Cornelius Katona, Roy W. Jones, Julia DeCesare, Michaela Rodger, Donepezil for the Treatment of Agitation in Alzheimer's Disease, 357, 1382-1392. Copyright © 2007 Massachusetts Medical Society. Reprinted with permission.
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