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Donepezil for the treatment of agitation in Alzheimer's disease.

Abstract:

BACKGROUND: Agitation is a common and distressing symptom in patients with Alzheimer's disease. Cholinesterase inhibitors improve cognitive outcomes in such patients, but the benefits of these drugs for behavioral disturbances are unclear. METHODS: We randomly assigned 272 patients with Alzheimer's disease who had clinically significant agitation and no response to a brief psychosocial treatment program to receive 10 mg of donepezil per day (128 patients) or placebo (131 patients) for 12 week...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1056/nejmoa066583

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Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, NPEU
Role:
Author
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Alzheimer's Society More from this funder
Publisher:
Massachusetts Medical Society Publisher's website
Journal:
The New England journal of medicine Journal website
Volume:
357
Issue:
14
Pages:
1382-1392
Publication date:
2007-10-05
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
URN:
uuid:7c793175-5022-4a6a-be4e-43efe035946e
Source identifiers:
60824
Local pid:
pubs:60824

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