- Abstract:
-
PURPOSE: Choroideremia (CHM) is a progressive X-linked degeneration of three ocular layers (photoreceptors, retinal pigment epithelium, and choroid), with a complex and still largely unclear pathogenesis. To investigate the pathophysiology of CHM, the authors engineered mice with a cell type-specific Chm/Rep1 knockout (KO). METHODS: A mouse line carrying a conditional allele Chm(Flox) was crossed with the transgenic line IRBP-Cre to achieve Chm KO, specifically in the photoreceptor layer, and...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1167/iovs.09-4892
-
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- Journal:
- Investigative ophthalmology and visual science
- Volume:
- 51
- Issue:
- 10
- Pages:
- 4913-4920
- Publication date:
- 2010-10-05
- DOI:
- EISSN:
-
1552-5783
- ISSN:
-
0146-0404
- URN:
-
uuid:7c6583a5-6556-41d9-8ff9-5ecd8bfc7994
- Source identifiers:
-
101647
- Local pid:
- pubs:101647
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia.
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