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Journal article

Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia.

Abstract:

PURPOSE: Choroideremia (CHM) is a progressive X-linked degeneration of three ocular layers (photoreceptors, retinal pigment epithelium, and choroid), with a complex and still largely unclear pathogenesis. To investigate the pathophysiology of CHM, the authors engineered mice with a cell type-specific Chm/Rep1 knockout (KO). METHODS: A mouse line carrying a conditional allele Chm(Flox) was crossed with the transgenic line IRBP-Cre to achieve Chm KO, specifically in the photoreceptor layer, and...

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Publication status:
Published

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Publisher copy:
10.1167/iovs.09-4892

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Biomedical Research Centre
Role:
Author
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Journal:
Investigative ophthalmology and visual science
Volume:
51
Issue:
10
Pages:
4913-4920
Publication date:
2010-10-05
DOI:
EISSN:
1552-5783
ISSN:
0146-0404
URN:
uuid:7c6583a5-6556-41d9-8ff9-5ecd8bfc7994
Source identifiers:
101647
Local pid:
pubs:101647

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