Journal article
Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion.
- Abstract:
-
Hippocampal NMDA receptors (NMDARs) and NMDAR-dependent synaptic plasticity are widely considered crucial substrates of long-term spatial memory, although their precise role remains uncertain. Here we show that Grin1(ΔDGCA1) mice, lacking GluN1 and hence NMDARs in all dentate gyrus and dorsal CA1 principal cells, acquired the spatial reference memory water maze task as well as controls, despite impairments on the spatial reference memory radial maze task. When we ran a spatial discrimination ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/nn.3166
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Authors
Bibliographic Details
- Journal:
- Nature neuroscience
- Volume:
- 15
- Issue:
- 8
- Pages:
- 1153-1159
- Publication date:
- 2012-08-01
- DOI:
- EISSN:
-
1546-1726
- ISSN:
-
1097-6256
- Source identifiers:
-
342289
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:342289
- UUID:
-
uuid:7c64d113-b71e-48c9-8f1b-5369273e2b1f
- Local pid:
- pubs:342289
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
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