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Journal article

Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion.

Abstract:

Hippocampal NMDA receptors (NMDARs) and NMDAR-dependent synaptic plasticity are widely considered crucial substrates of long-term spatial memory, although their precise role remains uncertain. Here we show that Grin1(ΔDGCA1) mice, lacking GluN1 and hence NMDARs in all dentate gyrus and dorsal CA1 principal cells, acquired the spatial reference memory water maze task as well as controls, despite impairments on the spatial reference memory radial maze task. When we ran a spatial discrimination ...

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Publication status:
Published

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Publisher copy:
10.1038/nn.3166

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Journal:
Nature neuroscience
Volume:
15
Issue:
8
Pages:
1153-1159
Publication date:
2012-08-05
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:7c64d113-b71e-48c9-8f1b-5369273e2b1f
Source identifiers:
342289
Local pid:
pubs:342289

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