- Abstract:
-
In forced-swim tests in mice and rats, the novel D(3)/D(2) receptor agonist S32504 [(+)-trans-3,4,4a,5,6,10b-hexahydro-9-carbamoyl-4-propyl-2H-naphth[1,2-b]-1,4-oxazine] dose-dependently (0.04-2.5 mg/kg) and stereospecifically suppressed immobility compared with its enantiomer S32601 [(-)-trans-3,4,4a,5,6,10b-hexahydro-9-carbamoyl-4-propyl-2H-naphth-[1,2-b]-1,4-oxazine]. Ropinirole was less potent than S32504 in this procedure, and it was likewise less potent than S32504 (0.04-2.5 mg/kg) in a...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1124/jpet.103.062463
-
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- Journal:
- The Journal of pharmacology and experimental therapeutics
- Volume:
- 309
- Issue:
- 3
- Pages:
- 936-950
- Publication date:
- 2004-06-05
- DOI:
- EISSN:
-
1521-0103
- ISSN:
-
0022-3565
- URN:
-
uuid:7c5ecafa-1101-42c8-b170-299341bb0f14
- Source identifiers:
-
185237
- Local pid:
- pubs:185237
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: III. Actions in models of potential antidepressive and anxiolytic activity in comparison with ropinirole.
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