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S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: III. Actions in models of potential antidepressive and anxiolytic activity in comparison with ropinirole.

Abstract:

In forced-swim tests in mice and rats, the novel D(3)/D(2) receptor agonist S32504 [(+)-trans-3,4,4a,5,6,10b-hexahydro-9-carbamoyl-4-propyl-2H-naphth[1,2-b]-1,4-oxazine] dose-dependently (0.04-2.5 mg/kg) and stereospecifically suppressed immobility compared with its enantiomer S32601 [(-)-trans-3,4,4a,5,6,10b-hexahydro-9-carbamoyl-4-propyl-2H-naphth-[1,2-b]-1,4-oxazine]. Ropinirole was less potent than S32504 in this procedure, and it was likewise less potent than S32504 (0.04-2.5 mg/kg) in a...

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Publication status:
Published

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Publisher copy:
10.1124/jpet.103.062463

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Journal:
The Journal of pharmacology and experimental therapeutics
Volume:
309
Issue:
3
Pages:
936-950
Publication date:
2004-06-05
DOI:
EISSN:
1521-0103
ISSN:
0022-3565
URN:
uuid:7c5ecafa-1101-42c8-b170-299341bb0f14
Source identifiers:
185237
Local pid:
pubs:185237

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