Journal article icon

Journal article

Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.

Abstract:

Fission yeast Cut5/Rad4 plays a unique role in the genome maintenance as it is required for replication, replication checkpoint, and normal UV sensitivity. It is unknown, however, how Cut5 protein is linked to other checkpoint proteins, and what part it plays in replication and UV sensitivity. Here we report that Cut5 interacts with a novel checkpoint protein Crb2 and that this interaction is needed for normal genome maintenance. The carboxyl terminus of Crb2 resembles yeast Rad9 and human 53...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1101/gad.11.24.3387

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Matsusaka, T More by this author
Mochida, S More by this author
Yanagida, M More by this author
Journal:
Genes and development
Volume:
11
Issue:
24
Pages:
3387-3400
Publication date:
1997-12-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
URN:
uuid:7c5b7581-dcff-4ea5-bb34-320ad982faed
Source identifiers:
55430
Local pid:
pubs:55430

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP