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Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.

Abstract:

Exonuclease 1 (EXO1) is a candidate gene for colorectal tumor susceptibility because it is believed to play a role in mismatch repair. There have been several studies investigating the role of EXO1 in mismatch repair but few investigating its role in causing clinical disease. In one recent study, germline variants of EXO1 were reported to be associated with predisposition to colorectal cancer in families with phenotypes similar to hereditary nonpolyposis colon cancer (HNPCC). We recently iden...

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Authors


Jaeger, EE More by this author
Kelsell, D More by this author
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Journal:
Cancer genetics and cytogenetics
Volume:
147
Issue:
2
Pages:
121-127
Publication date:
2003-12-05
DOI:
EISSN:
1873-4456
ISSN:
0165-4608
URN:
uuid:7c50de5d-a33b-4922-bd28-b85b273ef50a
Source identifiers:
72220
Local pid:
pubs:72220

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