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In vitro binding of HFE to the cation-independent mannose-6 phosphate receptor.

Abstract:

Hereditary hemochromatosis is most frequently associated with mutations in HFE, which encodes a class Ib histocompatibility protein. HFE binds to the transferrin receptor-1 (TfR1) in competition with iron-loaded transferrin (Fe-Tf). HFE is released from TfR1 by increasing concentrations of Fe-Tf, and free HFE may then regulate iron homeostasis by binding other ligands. To search for new HFE ligands we expressed recombinant forms of HFE in the human cell line 293T. HFE protein was purified, bi...

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Publication status:
Published

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Publisher copy:
10.1016/j.bcmd.2009.03.010

Authors


Schimanski, LM More by this author
Drakesmith, H More by this author
Sweetland, E More by this author
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Journal:
Blood cells, molecules and diseases
Volume:
43
Issue:
2
Pages:
180-193
Publication date:
2009
DOI:
EISSN:
1096-0961
ISSN:
1079-9796
URN:
uuid:7c4db443-9fe9-4bb3-a4d5-7692a800b930
Source identifiers:
24032
Local pid:
pubs:24032

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