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beta-Adrenoceptor agonists enhance 5-hydroxytryptamine-mediated behavioural responses.

Abstract:

The beta-adrenoceptor agonists, salbutamol, terbutaline and clenbuterol, were investigated for their effect on 5-hydroxytryptamine-mediated (5-HT) hyperactivity. 2 The lipophilic beta-adrenoceptor agonist, clenbuterol (5 mg/kg) enhanced the behaviours induced by quipazine (25 mg/kg), including headweaving, forepaw treading and hind-limb abduction and thus increased automated activity recording. Clenbuterol (5 mg/kg) also enhanced the hyperactivity syndrome produced by the 5-HT agonist, 5-meth...

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Publication status:
Published

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Authors


Grahame-Smith, DG More by this author
Journal:
British journal of pharmacology
Volume:
76
Issue:
2
Pages:
265-270
Publication date:
1982-06-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:7c2812e9-7dc6-4c36-a2cf-e8b375920cf2
Source identifiers:
185965
Local pid:
pubs:185965

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