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Thesis

Studies towards the stereoselective synthesis of alkenes

Abstract:

The work presented in this thesis mainly describes the development of new reactions of β-lithiooxyphosphonium ylides to access stereodefined substituted alkenes in a highly convergent fashion.

Firstly, β-lithiooxy ylides prepared from aldehydes and phosphonium ylides were shown to react with halogen electrophiles to provide a highly stereoselective route to E-alkenyl bromides and iodides. This methodology was successfully applied to the first total synthesis of naturally oc...

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Institution:
University of Oxford
Oxford college:
Lincoln College
Department:
Mathematical,Physical & Life Sciences Division

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Role:
Supervisor
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:7c1fffe2-1bf5-4c8c-bfb7-d46dd4a68342
Local pid:
ora:11979

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