Journal article
A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes
- Abstract:
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Transcriptional regulation by chromatin is a highly dynamic process directed through the recruitment and coordinated action of epigenetic modifiers and readers of these modifications. Using an unbiased proteomic approach to find interactors of H3K36me3, a modification enriched on active chromatin, here we identify PWWP2A and HDAC2 among the top interactors. PWWP2A and its paralog PWWP2B form a stable complex with NuRD subunits MTA1/2/3:HDAC1/2:RBBP4/7, but not with MBD2/3, p66α/β, and CHD3/4....
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(pdf, 3.6MB)
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- Publisher copy:
- 10.1038/s41467-018-06235-9
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Authors
Funding
+ Natural Sciences and Engineering Research Council of Canada
More from this funder
Funding agency for:
Zhang, T
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 9
- Pages:
- 3798
- Publication date:
- 2018-09-18
- Acceptance date:
- 2018-08-03
- DOI:
- EISSN:
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2041-1723
Item Description
- Pubs id:
-
pubs:907631
- UUID:
-
uuid:7c1c4256-1e66-4980-b6a2-c772c67996c2
- Local pid:
- pubs:907631
- Deposit date:
- 2018-08-16
Terms of use
- Copyright holder:
- Zhang et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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