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A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes

Abstract:

Transcriptional regulation by chromatin is a highly dynamic process directed through the recruitment and coordinated action of epigenetic modifiers and readers of these modifications. Using an unbiased proteomic approach to find interactors of H3K36me3, a modification enriched on active chromatin, here we identify PWWP2A and HDAC2 among the top interactors. PWWP2A and its paralog PWWP2B form a stable complex with NuRD subunits MTA1/2/3:HDAC1/2:RBBP4/7, but not with MBD2/3, p66α/β, and CHD3/4....

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-06235-9

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Millard, C More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
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Funding agency for:
Zhang, T
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Pages:
3798
Publication date:
2018-09-18
Acceptance date:
2018-08-03
DOI:
EISSN:
2041-1723
Pubs id:
pubs:907631
URN:
uri:7c1c4256-1e66-4980-b6a2-c772c67996c2
UUID:
uuid:7c1c4256-1e66-4980-b6a2-c772c67996c2
Local pid:
pubs:907631

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