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A method of inducing global cerebral ischemia

Abstract:
The four-vessel occlusion (4-VO) method of global forebrain cerebral ischemia mimics the human clinical condition of cardiac arrest. It results in selective neuronal damage and is a useful experimental system to dissect underlying mechanisms behind ischemic phenomena such as the differential susceptibility of CA1 compared to the CA3 region of the hippocampus. It also provides a "proof-of-principle" system for testing out potential agents for neuroprotection. © 2014 Springer Science+Business Media New York.

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Authors


Papadakis, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Publisher:
Humana Press Inc.
Journal:
Methods in Molecular Biology
Volume:
1135
Pages:
111-120
Publication date:
2014
DOI:
ISSN:
1064-3745
URN:
uuid:7c102ce3-6f93-4b96-a282-8fac174172f0
Source identifiers:
474097
Local pid:
pubs:474097
Language:
English
Keywords:

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